The Merge Madness Event in Plants vs Brainrots has added one of the most exciting new mechanics to the game, which is the Mutation Machine. This new feature lets you merge two plants or brainrots with different mutations to create powerful fusion variants that inherit both mutation bonuses. But using this isn't as simple as you might think, as there are various nuances you need to consider. So, to help you do it right, here's a complete Merge Madness event guide for Plants Vs Brainrots.
How to Merge Mutations in Plants vs Brainrots

To start merging, you’ll need access to the Mutation Machine located on Central Island, unlocked once you reach Rebirth 1. The Mutation Machine lets you combine two of the same plants or brainrots (like 67, Tomatrio, or Matteo), each with a different mutation.
To merge mutations of the Brainrots or Plants, you will need two of the same units, but with different mutations. Once you have that, follow the steps mentioned below to merge them.
How to Use Mutation Machine in Plants vs Brainrots

The Mutation Machine functions similarly to the Fuse Machine, but instead of combining rarities, it fuses mutations for new hybrid effects. Here are all the steps you need to follow:
- Travel to Central Island: Use the mirror at your base to teleport. The Mutation Machine is right beside the Plant Extractor and EXP Machine.
- Insert Mutated Plants or Brainrots: Press E while holding a mutated plant/brainrot to slot it in. Both must share the same type but differ in mutation.
- Charge with EXP Items: Add 300 EXP to the machine using bottles, vials, or flasks. These are earned through the Plant Extractor, which converts unwanted plants into EXP items.
- Merge Mutations: Once the machine is powered, hit Mix to start merging. The process duration depends on the rarity tier, but during Mutation Mania weather, it’s completed twice as fast.
- Claim & Repeat: Collect your newly fused plant or brainrot and repeat merges to progress through the event reward ladder.
The overall process is quite simple. For example, if you combine a Plant with Frozen and Neon mutations, the Frozen’s slowing effect with Neon’s glow multiplier will create a single Plant with both effects.
All Plants vs Brainrots Mutation Machine Rewards
Each completed mutation merge earns you exclusive rewards during the Merge Madness event. These include powerful brainrots, seeds, and premium items that boost your progress. Below, we've mentioned all the currently discovered event rewards:
| Merge Count | Reward | Type |
|---|---|---|
| 1 | 8.7B Cash | Cash |
| 2 | 3 Premium Water Bucket + 8.7B Cash | Resources |
| 3 | 1 Orcalero Orcala + 3 Frost Grenade | Brainrot/Item |
| 4 | 8.7B Cash | Cash |
| 5 | 1 Sunflower Seed + 3 Premium Water Bucket + 2 Base Card Packs | Mixed |
| 6 | Witch Potion | Item |
| 7 | Gangster Footera + Cash | Brainrot |
| 8 | Sunflower Seed + Cash | Seed |
| 9 | Dragon Fruit Seed + Bandito Bobrito + Cash | Brainrot/Seed |
| 10 | 8.7B Cash | Cash |
| 11 | Frost Grenade + Orcalero Orcala | Item/Brainrot |
| 12-21 | TBA | TBA |
| 22 | Dr. Flalarino + Blohazellno Seed | Brainrot/Seed |
Frequently Asked Questions (FAQs)
Yes, as long as both belong to the same base type (e.g., two 67s). The result inherits both mutations and boosted stats.
No, the mutations must differ. For example, Frozen + Neon works, but Frozen + Frozen won’t.
New mutation types include Foggy, Electrified, Scorched, and Stormy, each with a 2x value multiplier when merged.
Not multiplicatively. The resulting fusion typically gains 1-2x the stats of the weaker plant or brainrot merged, balancing power growth and progression.
For more on Plants Vs Brainrots, check out Plants Vs Brainrots Mutations Guide or Complete Plants Vs Brainrots Storyline Update Guide on Pro Game Guides!