Plague Inc. Nano-Virus Normal Guide – Tips on How to Complete!

Nano-Virus is an interesting type of plague in Plague Inc., as you begin a game with humanity immediately being aware of it and working double-time to “cure” it. We say “cure”, as it’s more of a kill-code that deactivates the virus.

A Nano-Virus is a man-made form of plague that looks like a microscopic robot and can replicate itself. It shares many of the same symptoms and transmissions as the regular virus, so the actual gameplay doesn’t change too much, but your strategy will absolutely have to.

And that’s where we come in. We’ve put together a recommended strategy, tips, and more below that will help you master this plague type on Normal difficulty.

What is a Nano-Virus?

A Nano-Virus is an artificially created microscopic robot that has the ability to replicate itself inside its host’s body. Aside from that, it basically functions like any other virus, with plenty of the same symptoms and transmissions making an appearance.

A Nano-Virus can’t be cured though. Instead, you have to broadcast a kill-code, which will force all of the Nano-Viruses to shut down. This doesn’t change anything in gameplay terms though.

How Does the Nano-Virus Differ in Terms of Gameplay?

Quite considerably, actually. While with most of the plague types in Plague Inc. you’ll want to fly under the radar until you’ve infected everyone, you don’t have that choice here. From the moment the game starts, humanity is already aware of the Nano-Virus and will actively work on a cure, or kill-code.

That means that time is of the essence with this play style. While we’ll get into a general strategy in more depth later, your early game goal is very different. Sure, you’ll still prioritize infecting as much of the population as possible, but you’ll also want to slow development of the cure. Both are as important as each other at this point.

Nano-Virus Strategy

We managed to beat Nano-Virus on Normal on our first attempt. It was messy, and took us longer than we’d have liked, but it’s not overly challenging. We thought that stalling the cure would pose the biggest challenge but it’s actually infecting every country in time.

Here’s the strategy that worked for us. Given the random nature of Plague Inc., we won’t simply give you a bunch of steps to follow that will guarantee victory, but we will provide you with the information you need to succeed.

  1. Infect the world’s population. Get Air 1 and 2, Water 1 and 2, Extreme Bioaerosol, Cold/Heat Resistance 1 and 2 (get the opposite of the temperature of the country you started in) and Drug Resistance 1 and 2.
  2. Slow down the cure. Get Code Fragment Interception and Code Segment Interception as early as possible in the game to severely slow down the cure. As soon as the cure reaches 50%, get Radical Elements Stabilized then get Encryption Breached when it tops back up to 50%. Ignore Broadcast Interceptor Overload and Replication Factory Overload for now.
  3. Once the world is completely infected, get Total Organ Failure by following any path of the Symptoms tree through the tiers. We prefer Insomnia, as it’s free and also slows down cure research.
  4. Watch as the world burns. Spend your remaining DNA points on Genetic Reshuffle 1, 2, and 3 to slow down the cure. You can also speed up the kill rate by grabbing Hemorrhagic Shock and Necrosis. At this point though, humanity should be beyond help.

General Nano-Virus Tips

We’re just going to quickly fill in the gaps in our strategy to provide a few tips that didn’t make it into our strategy.

  • You can grab Insomnia before you choose your starting country. It’s free and can slightly slow down cure research. Every little helps.
  • Devolve any lethal traits that you get through mutation immediately, as these can lead to countries closing their borders. Given the difficulty of infecting the planet with this type of plague, you don’t want to make life harder for yourself. It’s not the end of the world though, as you can spend DNA points on further transmissions to mitigate this issue somewhat.
  • It doesn’t matter where you start, though you do need to remember the temperature of the country. It’s vital that you get resistance to the opposite temperature or you’ll struggle to infect the entire planet.
  • Broadcast Interceptor Overload and Replication Factory Overload are completely unnecessary on Normal, so you can save your DNA Points. They’re basically panic buttons that slightly punish you for using them. You’re best off not needing to.
  • You will have to exercise some patience and restraint on this mode – particularly when it comes to DNA points. Provided you follow our strategy above, and don’t spend them on stuff you don’t need, you should have plenty left over once the world starts burning. The key is not to overspend initially, as you’re going to need over 50 at least to get Total Organ Failure once the planet is fully infected.
  • As in our other guides, you can devolve all Transmissions, Heat/Cold Resistance, and Drug Resistance as soon as the entire world is infected, freeing up plenty of points to spend on Symptoms. Never devolve Code Fragment Interception or Radical Elements Stabilized Tiers 1 and 2 though, as you still need cure progress to remain slow.
  • These tips are not for a speed mode, which requires a totally different strategy. Our guide is designed to avoid risk and to help you complete Normal difficulty with ease.
Follow us on Twitter and Facebook to get updates on your favorite games!

Recently Updated Plague Inc. Posts

Leave a Comment

Comments are on moderation and will be approved in a timely manner. Please read the following rules before commenting:

  • All comments must be on topic and add something of substance to the post
  • No swearing or inappropriate words
  • No asking or begging for anything free
  • Do not attempt to start a poll in the comments
  • Comments in all CAPS will be removed
  • We reserve the right to remove a comment for any reason
  • Do not impersonate a staff member or influencer

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.


  1. Whoah! The cure is fast! I haven’t started the game and there is the cure already!

  2. much better then the vast majority but i can simplify it even further.
    whats nice about the nanovirus mode is its quick,i won first time in 391 days thx to this guide, so this helps get new genes fast.
    in this mode symptoms are cheap and should be used 4 fold more then in any other mode, but do not evolve lethal ones because that accelerates the cure.
    heres what you do:

    beg evolve insomnia, paranoia and anemia this s!ows down cure so u aint freaking out
    then you evolve the two virus abilities just first tier
    then you focus on transmission, i love starting in egypt so for me i only do 1 air, 1 water, 1 insect and 2 blood.

    since i pick egypt, i do 2 cold, 0 heat, 1 drug (because i got 2 blood which gets more dna/faster infection then drug 2)

    after that im almost laughing, normally i would hold back on symptoms, but its stupid not to evolve coughing, nausea, vomiting because now the world is at my mercy, did i mention the cure was at 35% when i won the first time…also pneumonia and hypersensitivity ….u got unbeatable transmission short of wasted dna for aerosole. when over 6.5 billion ppl and every country is infected use necrosis since it kills s!ower then infection rate then when no healthy ppl left unleash total organ failure and hemorrhaging shock..and so on and so forth

    i garantee this even works on brutal difficulty

  3. it doesn’t work i tried two times but each everyone already new about it and used full research

  4. the strategy works with brutal aswell by the way

  5. Thanks. Took me 927 days starting from Saudi Arabia with Cure Progress 70%.
    I was hard from the beginning as the cure start to be discovered very fast, but as soon as more people get infected i was able to slow down the cure.

    1. yeah know what you mean it is hard. i started from ukraine on brutal and i did it in 1002 days. just a tip: get both overloads to get a cure-stalling ability.

  6. 841days 65% cure thanks to your tips..had to improvise a bit but it went well in the long run thanks!